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Cigarette smoke also contains carbon monoxide, a gas that reduces the amount of oxygen carried in the bloodstream

[1] While the cause of these differing concentrations of minor tobacco alkaloids is unknown, Lisko and colleagues (2015) speculated potential reasons may derive from the e-liquid extraction process (i.e., purification and manufacturing) used to obtain nicotine from tobacco, as well as poor quality control of e-liquid products

Nicotine can cause side effects in the heart, hormones, and gastrointestinal system

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Like cigarettes, smokeless tobacco products contain a variety of toxins associated with cancer